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Experimental glioblastoma therapy shows curative powers in mice models — ScienceDaily

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug. This mitochondrial-targeted prodrug — an inactive compound that cancer cells selectively metabolize to produce an active toxic drug — also greatly improves outcomes when coupled with standard therapies of radiation and/or chemotherapy. The drug selectively targets and destroys the DNA inside the glioblastoma cell mitochondria (the energy factory of the cancer cell) leaving normal cells intact.

In an Oct. 8 study published online in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, investigators used a second generation prodrug called MP-Pt(IV) to target the deadly cells of glioblastoma tumors, a brain cancer that is almost always fatal and has no cure. Life expectancy in humans with glioblastoma ranges from a few months to two years.

Human glioma cells were removed

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Sims powers Georgia Tech past fumble-prone Louisville, 46-27

Georgia Tech (2-2, 2-1 Atlantic Coast Conference) snapped a two-game losing streak. Sims, a freshman, passed for 249 yards with two touchdowns, including a 34-yard scoring pass to Malachi Carter to extend the lead with less than three minutes remaining. Dontae Smith added a 12-yard scoring run in the final minute.

Louisville (1-3, 0-3) suffered its third straight loss despite a strong effort by quarterback Malik Cunningham, who passed for 229 yards with two touchdowns and ran for two scores.

Cunningham did not throw an interception. It was a dramatic return to form for the junior quarterback, who threw a career-high three interceptions and was sacked seven times in a 23-20 loss to Pittsburgh on Sept. 26. Before the loss to Pitt, Cunningham had never thrown more than one interception in a game.

Cunningham completed scoring passes to Marshon Ford and Tutu Atwell. His second touchdown run, an 11-yarder late

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